Veterinary Vaccines

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Bovine enterotoxemia caused by Clostridium perfringens is a sudden death syndrome with necrotic lesions in the small intestine that primarily affects lactating and fattening calves. For calf fattening, mainly beef cattle breeds are affected. The syndrome accounts for approximately 20% of these calves compared to 4% in dairy and hybrid calves.

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Sepsis occurs when bacteria enter the bloodstream and circulate throughout the body. They damage internal organs and can lead to calf death from multiple organ failure.Usually the bacteria enter the blood through other infections such as umbilical cord infections, pneumonia and diarrhea.

Blackleg is an acute, highly fatal disease of cattle and sheep caused by Clostridium chauvoei. In cattle, characteristic lesions of emphysematous swelling of muscles often occur without a history of wounds. In contrast, sheep diseases are most often the result of wound infections after shearing, docking, castration, etc. This disease is very deadly.

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Infectious bronchitis is an acute, highly contagious disease of the upper respiratory tract of chickens. In addition to respiratory signs, poor egg production and quality are common, and nephritis can be caused by some strains.Although live-attenuated and inactivated vaccines are available. , the different antigenic species of the avian coronavirus that cause this disease are unable to protect each other, complicating control efforts.

The vaccine contains at least 103.5 EID50 live attenuated avian infectious bronchitis

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The vaccine has proven to be harmless and stress-free when administered to day-old chicks and laying hens. Under normal conditions, it provides robust immunity (95% protection) to vaccinated chicks. In most fowlpox-prone areas, two doses of vaccination (repeated at 4-5 weeks of age and again at 14-15 weeks of age) completely prevent the disease.

Fowlpox (FP) is a viral disease of chickens, turkeys, and many other birds characterized by cutaneous lesions of wingless skin and/or diphtheria lesions of the mucous membranes of the upper gastrointestinal and respiratory tracts. FP occurs with the cutaneous or diphtheria type, or both. Cutaneous forms predominate in most outbreaks. Lesions vary by developmental stage.

Papules, vesicles, pustules or crusts. Lesions are mainly located in the head area.

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This 'RB' strain vaccine has been shown not to cause stress, lameness, and mortality, which were common features of available R2B strain vaccines until recently. However, there is no significant decrease in egg production. Broilers can be vaccinated at 3-4 weeks of age.The vaccine contains live, attenuated Ranikhet disease ‘RB’ strain virus propagated in SPF chicken eggs, in freeze dried form. 

It has been shown to confer robust immunity in vaccinated chicks for 9 months under normal conditions. It has been used to control the development of Ranikhet disease within 48 hours when co-administered with the 'F' strain vaccine.

This vaccine is safe for birds under 5 weeks, There is no post-vaccination stress, lameness or mortality. Recommended for use during outbreak as a booster.

Immunization with the 'RB' vaccine is recommended to control outbreaks in combination with oral Ranikhet disease 'F' strain vaccine.

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Sheeppox and goatpox are viral diseases of sheep and goats characterized by fever, generalized papules or nodules, vesicles (rarely), internal lesions (especially pulmonary), and mortality. Both diseases are caused by capripoxvirus strains that infect all sheep and goats.

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Black Quarter is a systemic infection of cattle caused by Clostridium chauboyi. It is characterized by emphysematous swelling of the muscles, especially the buttocks. The incubation period is 1-5 days. The beginning is sudden. The first symptom is lameness with or without fever. The swelling is small, hot, and painful at first. They can occur in the muscles of the shoulders, hips, chest, back and sides. Within hours, the swelling becomes widespread and creaking.

Common symptoms are complete anorexia, marked weakness, muscle tremors, congestion of mucous membranes, dyspnea, rapid heart rate, and high fever.

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Turkeypox is a disease of turkeys caused by a DNA virus of the genus Avipoxvirus,

Poxvirus family. Its distribution is spread all over the world. It spreads slowly and is characterized by proliferative lesions and crusting of the skin, and diphtherian lesions of the upper gastrointestinal and respiratory tracts.

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Ranikhet disease The Lasota strain is a lentogenic strain. Also known as Newcastle disease vaccine, Live, Roentgen strain. Fairly safe for 1- to 7-day-old soft chicks, including laying hens. It gives a very good immunity that lasts about 6 weeks. 

Newcastle disease is an infection of poultry and other bird species by the pathogenic Newcastle disease virus (NDV). It is a global problem and presents primarily as an acute respiratory illness, although depression, neurological symptoms, or diarrhea may be the predominant clinical forms.

Vaccination schedule include primary dose in 1-7 days and Re-vaccination is recommended 3 to 6 weeks later and booster at 16-18 weeks of age.

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Ranikhet disease ''''F'''' strains are lentogenic strains. It is the least stressed vaccine virus strain in its class. It can be used at any age, even layered, as a booster vaccine without affecting the egg-laying period. This vaccine contains live attenuated Ranikhet disease strain ''''F'''' virus grown in SPF chicken eggs and is available in lyophilized form. 

Newcastle disease is an infection of poultry and other bird species by the pathogenic Newcastle disease virus (NDV). It is a global problem and presents primarily as an acute respiratory illness, although depression, neurological symptoms, or diarrhea may be the predominant clinical forms.

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Newcastle disease mostly infects the airway, gut and  nervous system that includes dropping of wings, twisting of head and neck depression and complete paralysis in some cases. 

Newcastle disease is an infection of poultry and other bird species by the pathogenic Newcastle disease virus (NDV). It is a global problem and presents primarily as an acute respiratory illness, although depression, neurological symptoms, or diarrhea may be the predominant clinical forms.

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The vaccine is designed to provide protection against IBH and HPS infections in poultry in commercial and breeder birds. It is advised for use as a prelay and midlay vaccination in breeder flocks as well as for the vaccination of chicks in endemic areas.

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Rough skin disease is a poxvirus disease of cattle characterized by fever, nodules on the skin and mucous membranes of internal organs, weakness, enlarged lymph nodes, skin edema, and sometimes death. It is economically important as it leads to loss and skin damage. LSD is caused by strains of the Capripoxvirus that are antigenically indistinguishable from the strains that cause sheeppox and goatpox. However, bovine strains of Capripox do not infect or transmit sheep or goats, as evidenced by the differences in geographical distribution between LSD and sheep/goatpox.

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Infectious bronchitis is an acute, highly contagious disease of the upper respiratory tract of chickens. In addition to respiratory signs, poor egg production and quality are common, and nephritis can be caused by some strains.Although live-attenuated and inactivated vaccines are available. , the different antigenic species of the avian coronavirus that cause this disease are unable to protect each other, complicating control efforts.

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Rabies is a fatal neurological disease of dogs, especially dogs, wolves, jackals and mongooses, Caused by the rabies virus.

The incubation period varies from a few days to several months (usually 5-40 days), depending on the amount of virus injected at the time of the bite and its proximity to the brain, major nerve trunks, etc. The disease usually claims prey within almost 100 seconds. 5-10 days after the onset of clinical symptoms. Rabies is transmitted to all domestic animals through bites by rabid dogs and other dogs, and in most cases is fatal if left untreated.

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Pustular dermatitis contagiosum (ORF) is a highly contagious viral disease of sheep and goats characterized by the development of pustules and scaly lesions on the muzzle and lips. The disease is caused by the cutaneotropic ungulatepox virus. The virus is drought tolerant and can survive at room temperature for at least 15 years. The disease is most common in lambs between 3 and 6 months of age, but adult animals can also be severely affected.

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Foot-and-mouth disease is the most contagious animal disease and can cause severe losses in susceptible cloven-hoofed animals. There are seven serotypes of FMD virus: O, A, C, SAT1, SAT2, SAT3 and Asia 1. Infection with one serotype does not confer immunity to another serotype. A typical case of foot-and-mouth disease is characterized by a follicular condition of the feet, buccal mucosa, and female mammary glands. Clinical manifestations range from mild to severe and can be fatal, especially in young animals. Although all of the above FMD serotypes cause identical clinical symptoms, immunity to FMD is serotype-specific. Therefore, vaccination against all serotypes present in the community is indicated for protection.

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Avian cholera is a contagious bird disease caused by the bacterium Pasteurella multocida. A variety of wild and domestic birds are susceptible to infection, and avian cholera outbreaks in wild waterfowl are not uncommon. Avian cholera can be acute or chronic, generalized or localized, and is characterized by sudden onset with high morbidity and mortality. 

Avian cholera is said to be a hyperinfection that is transmitted through contact between healthy and sick birds in an environment contaminated with Pasteurella bacteria. Stress appears to be an important factor in overcoming a bird's resistance. Cold, damp weather predisposes birds to the disease, and outbreaks are commonly observed in flocks of wintering waterfowl during winter.

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The PPR vaccine is a live attenuated virus vaccine (Sungri 96 strain developed by I.V.R.I., India) manufactured using the Vero cell line adapted PPR virus. Viruses are grown in lyophilized Vero cells mixed with stabilizers. Peste des petits ruminants (PPR) is an acute, highly contagious, OIE notification required, and economically important transboundary virus of sheep and goats with high morbidity and mortality caused by PPR virus. It's also a sexually transmitted disease.